Coinfection with EBV/CMV and other respiratory agents in children with suspected infectious mononucleosis

Coinfection with EBV/CMV and other respiratory agents in children with suspected infectious mononucleosis

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Abstract Background Numerous studies have shown that Epstein-Barr virus (EBV) and cytomegalovirus (CMV) can infect immunocompetent patients simultaneously with other agents.Nonetheless, multiple infections with other agents in EBV/CMV-infected children have received lock shock and barrel art little attention.We conducted a retrospective study of children with suspected infectious mononucleosis.Peripheral blood samples were analyzed by indirect immunofluorescence to detect EBV, CMV and other respiratory agents including respiratory syncytial virus; adenovirus; influenza virus types A and B; parainfluenza virus types 1, 2 and 3; Chlamydia pneumoniae and Mycoplasma pneumoniae.A medical history was collected for each child.

Results The occurrence of multipathogen infections was 68.9%, 81.3% and 63.6% in the children with primary EBV, CMV or EBV/CMV, respectively, which was significantly higher than that in the past-infected group or the uninfected group (p C.pneumoniae in pet calming peanut butter children with primary infection was as high as 50%, significantly higher than in the other groups (p Conclusion Our study suggests that there is a high incidence of multipathogen infections in children admitted with EBV/CMV primary infection and that the distribution of these pathogens is not random.